Potential drug targets for Mycobacterium avium defined by radiometric drug-inhibitor combination techniques

combination techniques . defined by radiometric drug - inhibitor Potential drug targets for Mycobacterium avium

Potential drug targets for Mycobacterium avium defined by radiometric drug-inhibitor combination techniques.

Previously established radiometric techniques were used to assess the effectiveness of combined antimicrobial drug-inhibitory drug (drug-inhibitor) treatment on two clinical isolates of the Mycobacterium avium complex representing three colony variants: smooth opaque (dome) (SmO), smooth transparent (SmT), and rough (Rg). All variants were identified as members of the M. avium complex; however,...

Rapid radiometric method for determining drug susceptibility of Mycobacterium avium-intracellulare.

A rapid radiometric method for susceptibility testing of Mycobacterium avium-intracellulare to eight chemotherapeutic agents was compared with a conventional method. Results were available within 72 h by radiometric testing in contrast to 21 days by the conventional method. The radiometric and conventional methods agreed to 61% of the tests, but growth inhibition of greater than or equal to 50%...

Potential drug targets in Mycobacterium tuberculosis through metabolic pathway analysis

The emergence of multidrug resistant varieties of Mycobacterium tuberculosis has led to a search for novel drug targets. We have performed an insilico comparative analysis of metabolic pathways of the host Homo sapiens and the pathogen M. tuberculosis. Enzymes from the biochemical pathways of M. tuberculosis from the KEGG metabolic pathway database were compared with proteins from the host H. s...

New drug targets for Mycobacterium tuberculosis.

In spite of the availability of effective chemotherapy and Bacille-Calmette-Guerin (BCG) vaccine, tuberculosis remains a leading infectious killer world-wide. Many factors such as, human immunodeficiency virus (HIV) co-infection, drug resistance, lack of patient compliance with chemotherapy, delay in diagnosis, variable efficacy of BCG vaccine and various other factors contribute to the mortali...